Treatment for Gastroparesis - NIDDK (2024)

How do doctors treat gastroparesis?

How doctors treat gastroparesis depends on the cause, how severe your symptoms and complications are, and how well you respond to different treatments. Sometimes, treating the cause may stop gastroparesis. If diabetes is causing your gastroparesis, your health care professional will work with you to help control your blood glucose levels. When the cause of your gastroparesis is not known, your doctor will provide treatments to help relieve your symptoms and treat complications.

Changing eating habits

Changing your eating habits can help control gastroparesis and make sure you get the right amount of nutrients, calories, and liquids. Getting the right amount of nutrients, calories, and liquids can also treat the disorder’s two main complications: malnutrition and dehydration.

Your doctor may recommend that you

  • eat foods low in fat and fiber
  • eat five or six small, nutritious meals a day instead of two or three large meals
  • chew your food thoroughly
  • eat soft, well-cooked foods
  • avoid carbonated, or fizzy, beverages
  • avoid alcohol
  • drink plenty of water or liquids that contain glucose and electrolytes, such as
    • low-fat broths or clear soups
    • naturally sweetened, low-fiber fruit and vegetable juices
    • sports drinks
    • oral rehydration solutions
  • do some gentle physical activity after a meal, such as taking a walk
  • avoid lying down for 2 hours after a meal
  • take a multivitamin each day

If your symptoms are moderate to severe, your doctor may recommend drinking only liquids or eating well-cooked solid foods that have been processed into very small pieces or paste in a blender.

Controlling blood glucose levels

If you have gastroparesis and diabetes, you will need to control your blood glucose levels, especially hyperglycemia. Hyperglycemia may further delay the emptying of food from your stomach. Your doctor will work with you to make sure your blood glucose levels are not too high or too low and don’t keep going up or down. Your doctor may recommend

  • taking insulin more often, or changing the type of insulin you take
  • taking insulin after, instead of before, meals
  • checking your blood glucose levels often after you eat, and taking insulin when you need it

Your doctor will give you specific instructions for taking insulin based on your needs and the severity of your gastroparesis.

Medicines

Your doctor may prescribe medicines that help the muscles in the wall of your stomach work better. He or she may also prescribe medicines to control nausea and vomiting and reduce pain.

Your doctor may prescribe one or more of the following medicines:

  • Metoclopramide. This medicine increases the tightening, or contraction, of the muscles in the wall of your stomach and may improve gastric emptying. Metoclopramide may also help relieve nausea and vomiting.
  • Domperidone. This medicine also increases the contraction of the muscles in the wall of your stomach and may improve gastric emptying. However, this medicine is available for use only under a special program administered by the U.S. Food and Drug Administration.
  • Erythromycin. This medicine also increases stomach muscle contraction and may improve gastric emptying.
  • Antiemetics. Antiemetics are medicines that help relieve nausea and vomiting. Prescription antiemetics include ondansetron, prochlorperazine, and promethazine. Over-the-counter antiemetics include bismuth subsalicylate and diphenhydramine. Antiemetics do not improve gastric emptying.
  • Antidepressants. Certain antidepressants, such as mirtazapine, may help relieve nausea and vomiting. These medicines may not improve gastric emptying.
  • Pain medicines. Pain medicines that are not narcotic pain medicines may reduce pain in your abdomen due to gastroparesis.
Treatment for Gastroparesis - NIDDK (1)

Oral or nasal tube feeding

In some cases, your doctor may recommend oral or nasal tube feeding to make sure you’re getting the right amount of nutrients and calories. A health care professional will put a tube either into your mouth or nose, through your esophagus and stomach, to your small intestine. Oral and nasal tube feeding bypass your stomach and deliver a special liquid food directly into your small intestine.

Jejunostomy tube feeding

If you aren’t getting enough nutrients and calories from other treatments, your doctor may recommend jejunostomy tube feeding. Jejunostomy feedings are a longer term method of feeding, compared to oral or nasal tube feeding.

Jejunostomy tube feeding is a way to feed you through a tube placed into part of your small intestine called the jejunum. To place the tube into the jejunum, a doctor creates an opening, called a jejunostomy, in your abdominal wall that goes into your jejunum. The feeding tube bypasses your stomach and delivers a liquid food directly into your jejunum.

Parenteral nutrition

Your doctor may recommend parenteral, or intravenous (IV), nutrition if your gastroparesis is so severe that other treatments are not helping. Parenteral nutrition delivers liquid nutrients directly into your bloodstream. Parenteral nutrition may be short term, until you can eat again. Parenteral nutrition may also be used until a tube can be placed for oral, nasal, or jejunostomy tube feeding. In some cases, parental nutrition may be long term.

Venting gastrostomy

Your doctor may recommend a venting gastrostomy to relieve pressure inside your stomach. A doctor creates an opening, called a gastrostomy, in your abdominal wall and into your stomach. The doctor then places a tube through the gastrostomy into your stomach. Stomach contents can then flow out of the tube and relieve pressure inside your stomach.

Gastric electrical stimulation

Gastric electrical stimulation (GES) uses a small, battery-powered device to send mild electrical pulses to the nerves and muscles in the lower stomach. A surgeon puts the device under the skin in your lower abdomen and attaches wires from the device to the muscles in the wall of your stomach. GES can help decrease long-term nausea and vomiting.

GES is used to treat people with gastroparesis due to diabetes or unknown causes only, and only in people whose symptoms can’t be controlled with medicines.

How can I prevent gastroparesis?

Gastroparesis without a known cause, called idiopathic gastroparesis, cannot be prevented.

If you have diabetes, you can prevent or delay nerve damage that can cause gastroparesis by keeping your blood glucose levels within the target range that your doctor thinks is best for you. Meal planning, physical activity, and medicines, if needed, can help you keep your blood glucose levels within your target range.

Treatment for Gastroparesis - NIDDK (2024)

FAQs

Treatment for Gastroparesis - NIDDK? ›

Metoclopramide: This medicine increases the movements in your digestive system, helping the food to pass through more quickly and efficiently. This is the only medication in the United States that is FDA approved to treat gastroparesis.

What is a successful treatment for gastroparesis? ›

Metoclopramide: This medicine increases the movements in your digestive system, helping the food to pass through more quickly and efficiently. This is the only medication in the United States that is FDA approved to treat gastroparesis.

What is the new treatment for gastroparesis? ›

Tradipitant, if approved, will be the first novel drug for patients with gastroparesis since 1979,” said Mihael H. Polymeropoulos, MD, Vanda's President, CEO and Chairman of the Board.

What is the new hope for gastroparesis? ›

New advances in drug therapy, botulinum toxin injection, and gastric electrical stimulation techniques have been introduced and might provide new hope to patients with refractory gastroparesis.

Has anyone ever recovered from gastroparesis? ›

There's no cure for gastroparesis, but medication and dietary changes can make living with this condition easier and improve the quality of your life.

Has anyone been cured of gastroparesis? ›

Gastroparesis is a chronic condition, and in most cases, it does not go away or have a definitive cure. However, its symptoms can be managed, and the progression of the condition can be slowed with appropriate treatment.

What not to do with gastroparesis? ›

What to Avoid
  • Too much fat. You'll want to limit solid foods high in fat. ...
  • High-fiber food. Some fruits and vegetables can be hard to chew. ...
  • Tough food. That includes meats like steak and roast, or anything with skin.
  • Dairy. You may not digest lactose very well.
Mar 17, 2024

What is the drug of choice for gastroparesis? ›

Gastroparesis is a delay in food emptying from the stomach. It can be an uncomfortable and painful condition. Some common medications used to treat gastroparesis include metoclopramide (Reglan), erythromycin, and domperidone. Antiemetics, like promethazine and ondansetron (Zofran), can also be used to help with nausea.

What can reverse gastroparesis? ›

Although there is no cure for gastroparesis, changes to the diet, along with medication, can offer some relief. Certain medications, such as some antidepressants, opioid pain relievers, and high blood pressure and allergy medications, can lead to slow gastric emptying and cause similar symptoms.

How did I cured my gastroparesis naturally? ›

How do doctors treat gastroparesis?
  1. eat foods low in fat and fiber.
  2. eat five or six small, nutritious meals a day instead of two or three large meals.
  3. chew your food thoroughly.
  4. eat soft, well-cooked foods.
  5. avoid carbonated, or fizzy, beverages.
  6. avoid alcohol.

Why are so many people getting gastroparesis? ›

Diabetes is the most common known underlying cause of gastroparesis. Diabetes can damage nerves, such as the vagus nerve and nerves and special cells, called pacemaker cells, in the wall of the stomach. The vagus nerve controls the muscles of the stomach and small intestine.

What is end of life gastroparesis? ›

Read about other symptoms at the end of life

This is called delayed gastric emptying or gastroparesis. Having surgery for pancreatic cancer or having diabetes can also cause the stomach to empty slowly. Symptoms that your stomach is emptying slowly include: feeling and being sick.

Does drinking more water help gastroparesis? ›

Drink adequate fluids during the day to meet hydration needs. If vomiting, sip on Pedialyte or Gatorade to replace electrolytes. Don't drink too much during a meal as this may fill up your stomach too quickly. Limit to ½ cup (4oz) of fluids with meals and wait 30 minutes after eating to continue drinking.

Can you eat salad with gastroparesis? ›

Fiber is hard work for the stomach and takes longer to empty. Examples of high fiber foods: whole grains, oatmeal, brown rice, quinoa, nuts and seeds, legumes, beans, corn, raw vegetables, Brussels sprouts, cauliflower, broccoli, kale, fruit skin and seeds, oranges, pineapple, dried fruit, coconuts. Avoid large salads.

How long does it take to get rid of gastroparesis? ›

The outlook depends on several factors, including the cause of the disorder. For instance, gastroparesis cases that develop due to a viral infection often go away relatively quickly after symptom onset, whereas once it develops, diabetic gastroparesis is usually a lifelong condition.

What is the first line treatment for gastroparesis? ›

The 2013 guideline from the American College of Gastroenterology recommends prokinetic agents as first-line therapy for gastroparesis.

What is the life expectancy of someone with gastroparesis? ›

Whether gastroparesis is associated with a shortened life expectancy remains unknown. In a first study, the 9-year follow-up of 86 patients with diabetic gastroparesis did not evidence an association between mortality rates and GE when adjusted for co-morbidities.

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