[PDF] Behavioural and neurochemical effects after repeated administration of N‐ethylpentylone (ephylone) in mice | Semantic Scholar (2024)

Most of the newly developed synthetic cathinones can be seen as analogs and replacements for once-popular compounds that have been declining in popularity as a result of legislative efforts.

It is shown that DA increased more significantly than 5‐HT, indicating a large potential for NEP abuse, and over 90% of plasma NEP was potentially distributed to the brain, indicating large and long‐lasting effects.

In this study, locomotor stimulation and sensitization, as well as anxiety-like behavior induced by NEP were studied in Sprague-Dawley rats, using the open field and elevated plus maze respectively.

This study constitutes the first evidence that an exposure to a low dose of M DPV during adolescence induces behavioural sensitization and provides a neurobiological basis for a relationship between MDPV and cocaine.

Mphedrone, administered alone at the dose not affecting locomotor activity of mice, enhanced the expression of nicotine-induced locomotor sensitization and decreased general antioxidant status and catalase activity as well as antioxidant enzymes activity in the hippocampus and prefrontal cortex.

The toxic effects of AMPH, METH and MDMA are summarized and some of the factors that are thought to underlie this toxicity are presented, which include oxidative stress, hyperthermia, excitotoxicity and various apoptotic pathways.

It is indicated that amphetamine mixtures produce deleterious effects, even when individual drugs are combined at negligible concentrations, and these effects are strongly exacerbated in hyperthermia, emphasizing the potential increased risks of ecstasy intake, especially whenhyperthermia occurs concurrently with polydrug abuse.

Pharmacological characterization of the synthetic cathinone, 3,4-methylenedioxypyrovalerone (MDPV; commonly referred to as a “bath salt”), is critical for understanding the abuse liability and neurotoxic potential of this and related agents and contributes to a growing pharmacological rubric for evaluating the ever-growing list of designer Cathinone-related stimulants.

Characteristics of people presenting with toxicity after exposure to the synthetic cathinone N-ethylpentylone (NEP), detected infrequently in episodes of drug toxicity in the UK between 2016 and 2019, especially in southern England.

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