Many Pain Medications Can Be Used for Spine-related Pain in Older Adults (2024)

Spine-related pain is increasingly common in older adults. While medications play an important role in pain management, their use has limitations in geriatric patients due to reduced liver and kidney function, comorbid medical problems and polypharmacy (the simultaneous use of multiple drugs to treat medical conditions).

Now a new review study has found acetaminophen is safe in older adults, but non-steroidal anti-inflammatories (ibuprofen) may be more effective for spine-related pain. Non-steroidal anti-inflammatories should be used short-term in lower dose courses with gastrointestinal precaution while corticosteroids show the least evidence for treating nonspecific back pain.

Additionally, nerve pain medications (gabapentin and pregabalin) can be used in older persons, with caution to dose and kidney function. Newer antidepressants (duloxetine) more so than older ones (nortriptyline) can help with spine-related pain, with attention to possible sedation and dizziness. Some muscle relaxants (baclofen and tizanidine) can be used in older persons, again accounting for kidney and liver function. Opioids have limited use in common spine-related pain, but can be used with caution in cases that don’t respond to treatment.

Many Pain Medications Can Be Used for Spine-related Pain in Older Adults (1)“Most older people experience neck or low back pain at some point, bothersome enough to see their doctor. Our findings provide a helpful medication guide for physicians to use for spine pain in an older population that can have a complex medical history,” explained corresponding author Michael D. Perloff, MD, PhD, assistant professor of neurology at BUSM and a neurologist at Boston Medical Center.

The researchers performed a literature review to assess the evidence-basis for medications used for spine-related pain in older adults, with a focus on drug metabolism and adverse drug reactions. They then provided their recommendations based on safe and effective dosing.

Among their findings:

  • Pain medicines gabapentin and pregabalin may cause dizziness or difficulty walking, but may have some benefit for neck and back nerve pain (such as sciatica) in older adults. They should be used in lower doses with smaller dose adjustments.
  • Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. Others (tizanidine, baclofen, dantrolene) may be helpful for neck and back pain, with the most evidence for tizanidine and baclofen. These should be used in reduced doses, avoiding tizanidine with liver disease and reducing baclofen dosing with kidney disease.
  • Older antidepressants are typically avoided in older adults due to their side effects, but nortriptyline and desipramine may be better tolerated for neck and back nerve pain at lower doses. Overall, newer antidepressants (namely duloxetine) have a better safety profile and good efficacy for spine-related nerve pain.
  • Tramadol may be tolerated in older adults, but has risk for sedation, upset stomach, and constipation. It may be used in lower doses after alternative medications have failed and works well with co-administered acetaminophen. Opioids are avoided due to their side effects and mortality risk, but low dose opioid therapy may be helpful for severe refractory pain with close monitoring of patients clinically.

According to the researchers, complementary medicine, physical therapy, injections and surgery all have a place to help older persons with spine-related pain. “Medications used at the correct dose, for the correct diagnosis, adjusting for preexisting medical problems can result in better use of treatments for spine pain,” added first author Jonathan Fu, a 2022 MD graduate from BUSM.

These findings appear online in the journal Drugs & Aging.

Many Pain Medications Can Be Used for Spine-related Pain in Older Adults (2024)

FAQs

Many Pain Medications Can Be Used for Spine-related Pain in Older Adults? ›

Rational therapeutic choices based on geriatric spine pain diagnosis are helpful, such as NSAIDs and acetaminophen for arthritic and myofascial-based pain, gabapentinoids or duloxetine for neuropathic and radicular pain, antispastic agents for myofascial-based pain, and combination therapy for mixed etiologies.

What is the best medicine for back pain in the elderly? ›

NSAIDs. NSAIDs are often the go-to drugs for back pain relief. They can be purchased over the counter (or, in higher doses, by prescription) and include ibuprofen (Advil) and naproxen (Aleve). NSAIDs help reduce pain, swelling, and inflammation in muscles and around damaged spinal discs or arthritic joints.

What analgesia is used for elderly patients? ›

Current guidelines promote paracetamol as the first-line analgesic for acute pain in older adults, whereas opioids are advised cautiously for moderate to severe acute pain. However, opioids come with a significant array of side effects, which can be more pronounced in older individuals.

How do you treat pain in the elderly? ›

In addition, frequently reassess and re-dose as needed to avoid undertreatment of pain while monitoring for adverse effects. Consider morphine (0.05-0.1 mg/kg IV or 4-6 mg fixed-dose PO) as first-line opioid analgesia for older adults in moderate to severe pain unresponsive to non-opioid oral analgesics.

What painkillers are good for spinal pain? ›

If your pain continues, your provider may suggest nonsteroidal anti-inflammatory drugs (NSAIDs). You can buy some NSAIDs, such as ibuprofen and naproxen, without a prescription. NSAIDs help reduce the swelling around the swollen disk or arthritis in the back.

What is the safest painkiller for the elderly? ›

Acetaminophen (Tylenol) is usually safer for older adults than other pain medicines. Topical pain medicines (also called topical analgesics) can also help.

What is a strong prescription painkiller for back pain? ›

Your doctor may also prescribe a medicine called an opioid for lower back pain. Weak opioids (such as codeine) may be given for moderate pain. For severe and persistent pain, you may need stronger opioids, such as morphine. You might have this with or without paracetamol.

What is the best nerve pain medication for the elderly? ›

Additionally, nerve pain medications (gabapentin and pregabalin) can be used in older persons, with caution to dose and kidney function. Newer antidepressants (duloxetine) more so than older ones (nortriptyline) can help with spine-related pain, with attention to possible sedation and dizziness.

What is the strongest drug for nerve pain? ›

Anticonvulsants are one of the most effective medications for treating nerve pain. Examples include pregabalin (Lyrica) and gabapentin (Neurontin). These medications are typically very effective in treating nerve pain, but they may also cause undesired side effects, such as: lethargy.

What are 5 drugs to avoid in the elderly? ›

While it's not a complete list, below we discuss important ones you should know and safer alternatives to consider.
  • Benadryl and older antihistamines. ...
  • Sleep medications. ...
  • Muscle relaxers. ...
  • Antispasmodics. ...
  • Seroquel and other antipsychotic medications. ...
  • Tricyclic antidepressants. ...
  • Barbiturates. ...
  • Indomethacin.
Nov 22, 2022

Which painkiller is best for long-term use? ›

Acetaminophen is generally a safe option to try first for many types of pain, including chronic pain. Ask your health care provider for guidance about other medications to avoid while taking acetaminophen.

What do you do when your chronic pain is unbearable? ›

How can I cope with chronic pain?
  1. Avoid smoking.
  2. Don't try to do too much. ...
  3. Eat a healthy diet.
  4. Exercise regularly.
  5. Get enough sleep.
  6. Manage your stress.
  7. Join a support group for chronic pain to learn from other people with similar conditions.
  8. Limit alcohol, which can cause more problems with sleep and pain.

What is the strongest natural painkiller? ›

Endorphins are the body's natural painkillers. Released by the hypothalamus and pituitary gland in response to pain or stress, this group of peptide hormones both relieves pain and creates a general feeling of well-being. The name of these hormones comes from the term "endogenous morphine."

What is best for spinal pain? ›

Acupuncture, massage, biofeedback therapy, laser therapy, electrical nerve stimulation and other nonsurgical spine treatments can make a difference for chronic back pain. Overall, the potential benefits of these strategies far outweigh their potential risks, so they are worth exploring.

How do you deal with severe spinal pain? ›

If your back pain is severe or not getting better, a GP may prescribe painkillers or medicines to relax the muscles in your back. Other treatments may be recommended if your pain does not get better after a few weeks. These include: group exercise sessions and physiotherapy.

What is the best painkiller for spinal stenosis? ›

Chlorzoxazone and Ibuprofen for Lumbar Spinal Stenosis: A 2019 study in Pain and Therapy highlighted the effectiveness of chlorzoxazone and ibuprofen together over ibuprofen alone for acute low back pain.

What is the number one medicine for back pain? ›

Best for fast back pain relief: Ibuprofen (Advil, Motrin)

Ibuprofen (Advil, Motrin) is an NSAID. NSAIDs work by decreasing pain and inflammation. Ibuprofen is available as branded medication and as a lower-cost generic.

What is the safest muscle relaxer for the elderly? ›

The Geriatric Lexi-Drugs database recommends the avoidance of muscle relaxants other than diazepam and tizanidine in patients older than age 65 years because efficacy and safety have not been established in geriatric patients.

What is the home remedy for back pain in old age? ›

Home treatments may include the following.
  1. Exercise to get muscles moving. A short walk, aerobics, yoga, water aerobics, swimming, or another low-impact activity may help alleviate back pain. ...
  2. Improve posture. ...
  3. Use heat and cold. ...
  4. Stretch. ...
  5. Apply a pain-relief cream. ...
  6. Try massage. ...
  7. Try Arnica. ...
  8. Switch shoes.

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