How Long Does Tramadol (Ultram) Stay In Your System? (2024)

Tramadol stays in a person’s system for about a day and a half. This drug is an opioid painkiller that is often sold under brand names such as Ultram, Conzip, or Ryzolt.

It’s difficult to know the exact amount of time that tramadol will be detectable, as this can be influenced by factors such as height, weight, age, and overall health. For example, if a person has a low-functioning kidney or liver, it will take longer for their body to process the medication.

Tramadol Half-Life

Although tramadol can stay in a person’s system for nearly two days, this drug has a half-life of 6.3 hours. This means that after six hours have passed, half the dose will remain in a person’s system.

Tramadol is often prescribed by physicians, as it is widely believed to be less addictive than other opioids. However, people can still become dependent on this medication.

If you or someone you love is unable to stop taking tramadol, you may want to consider an Vertava Health rehab program.

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How Long Does Tramadol (Ultram) Take To Work?

Tramadol is a fast-acting medication. People who take tramadol will likely feel the effects of the drug within 30-60 minutes. The peak concentration of tramadol is reached within two hours. This means that within the first hour or two after a person takes tramadol, they will likely experience side effects like analgesia (lessened pain) and sleepiness.

Drugs like tramadol are metabolized by the liver. If a person’s liver is well-functioning, this organ will then break tramadol down into agents called metabolites. Depending on a person’s metabolism and organ function, some may feel the drug’s effects faster than others.

Tramadol (Ultram) Detection Time

Tramadol can be detected in a person’s system anywhere from one to 36 hours after last use. This is an average estimate that can be impacted by a person’s body size, age, and metabolism.

People may be curious about tramadol detection time for several reasons. If a person has an upcoming drug screening, they may want to ensure the medication is cleared from their system.

Many workplaces and medical offices require drug screenings for a variety of reasons. If you have a legal prescription for tramadol and are worried about failing a drug test, simply alert the person administering the test to your prescription. They may ask for a copy of the prescription for their records.

Another reason people may wonder how long tramadol stays in the system is because of the other medications they take. Opioids like tramadol can be extremely dangerous when taken with other drugs, especially benzodiazepines.

Tramadol may also cause side effects such as dry mouth, insomnia, or headache. As the body processes the drug and peak levels decrease, these effects should diminish.

Drug Test Types That Detect Tramadol (Ultram)

Opioid analgesics like tramadol can be habit-forming. If a person takes tramadol for a long period of time, their body may begin to crave a higher dose of the drug. While less addictive than other opioids, tramadol should still be taken with caution.

This medication can result in tolerance, dependence, and addiction. Because of this, schools, doctors, and employers may require routine drug screenings that test for this opioid.

There are multiple drug screen types that can detect opioid-like tramadol, including:

  • Urine Screening: This is the most common type of drug test, and usually shows results from the past one to three days
  • Saliva Swab: Oral swab tests can detect tramadol for 24-36 hours after last use
  • Hair Test: While it’s uncommon to use a hair test for tramadol, hair follicle screenings can often detect substances up to 90 days after use

If you are unable to stop taking tramadol without experiencing withdrawal symptoms, you are likely dependent on the medication. Fortunately, effective treatment is available.

Factors That Influence How Long Tramadol (Ultram) Is In Your System

Like other prescription medications, people’s bodies have different reactions to tramadol. This can include how long the drug stays in a person’s system. Genetics, overall health status, and size can all play a part in determining how long tramadol will remain in your body.

Tramadol detection time can be altered by additional factors, including:

Age

Elderly people have slower metabolisms, which can impact how long tramadol remains in a person’s system. Additionally, people of advanced age may have lower functioning kidneys and liver, which means it will take longer for the body to clear the medication.

Amount Taken

People who take tramadol for an extended amount of time may have traces of the drug in the fatty tissues of the body. If a person takes large or frequent doses of the drug, tramadol will remain traceable for a longer period of time.

Body Mass Index (BMI)

Because tramadol is stored in the body’s fatty tissues, those who have a higher body mass index may have larger amounts of the drug in their system. A person’s BMI may also impact their overall organ function, including the rate at which their liver metabolizes drugs like tramadol.

How To Get Tramadol (Ultram) Out Of Your System

The safest way to get tramadol out of your system is with the help of a medical detox program. People who know they have an upcoming drug screening may attempt to stop taking the drug on their own, which can lead to acute withdrawal.

Opioid withdrawal can be difficult and uncomfortable. People who stop taking tramadol abruptly may experience symptoms like chills, nausea, vomiting, and anxiety.

It can be difficult to stop taking opioids like tramadol. Medically assisted detox programs can provide the support and supervision needed by people who are suffering from tramadol use and addiction.

In a medical detox setting, doctors may suggest a tapering schedule. This allows the patient to slowly decrease their dose of tramadol, in order to give their body time to adjust to not having the drug.

Even when a person tapers off slowly, they may still experience painful withdrawal symptoms. In a detoxification program, patients are provided with medication-assisted treatment that helps to relieve flu-like withdrawal symptoms.

Getting Treatment For Tramadol (Ultram) Use And Addiction

Many people can take tramadol without any issue. However, millions of Americans are currently battling an opioid use disorder. If you or someone you love is suffering from tramadol use, an inpatient rehab program can help.

Vertava Health provide on-site detox programs, at our rehab centers throughout the U.S. Once a person successfully detoxes from tramadol, they benefit by engaging in a blend of traditional and alternative therapies. Individual counseling, wilderness therapy, and 12-step support groups are offered at our inpatient rehab centers.

To learn more about how long tramadol stays in your system, or to find a Tramadol rehab program near you, contact an Vertava Health treatment specialist today.

How Long Does Tramadol (Ultram) Stay In Your System? (2024)

FAQs

How Long Does Tramadol (Ultram) Stay In Your System? ›

Tramadol hydrochloride, a commonly prescribed painkiller which is often sold in the US under the name of Ultram (other tramadol medications include the likes of brand names Conzip, Ryzolt, and Rybix ODT), typically remains in the human body for up to two days, following the last dose.

How many hours does it take for tramadol to get out of your system? ›

You will feel less pain around 30 to 60 minutes after taking standard tramadol. The pain relief wears off after 4 to 6 hours. Slow-release tramadol tablets and capsules can take a day or two to start working but the pain relief will last for longer.

How long does it take to wash out tramadol? ›

Based on excretion studies, WADA has stated that the washout period for Tramadol is 24 hours. This is the time it should take after the last therapeutic dose for tramadol to get out of your system to a level that should not result in a positive test (also known as an Adverse Analytical Finding).

Can tramadol cause a false positive on a urine test? ›

Tramadol and its metabolites can cause a false-positive Emit II+ PCP screen, and clinicians should use caution when interpreting urine drugs-of-abuse screens that use immunoassays.

How long after taking tramadol can I drive? ›

You should avoid driving, operating machinery or other activities that require mental alertness until you know how tramadol will affect you. If the drug continues to make you sleepy or impair your thinking or mental capacity, do not drive or perform any hazardous activities.

Is 50mg of tramadol a lot? ›

Tramadol 50 mg may be adequate as the initial dose for moderate pain. For moderate to severe pain, 50 - 100 mg as needed for relief, every four to six hours may be administered. Tramadol 100mg is usually more effective as the initial dose for more severe pain. The maximum daily dose should not exceed 400mg per day.

What happens if I take 2:50mg tramadol at once? ›

you take two single doses of Tramadol 50 mg capsules at once by mistake, this will generally not be harmful. If pain returns, continue taking Tramadol 50 mg Capsules as usual. If high doses are taken accidentally (e.g. a dose of more than two Tramadol 50 mg Capsules at once), a number of symptoms may occur.

How is tramadol cleared from the body? ›

Tramadol and its metabolites are mainly excreted via the kidneys. The mean elimination half-life is about 6 hours. The O-demethylation of tramadol to M1, the main analgesic effective metabolite, is catalysed by cytochrome P450 (CYP) 2D6, whereas N-demethylation to M2 is catalysed by CYP2B6 and CYP3A4.

What are the worst side effects of tramadol? ›

Serious side effects
  • feel dizzy, tired and have low energy – these can be a sign of low blood pressure.
  • have hallucinations (seeing or hearing things that are not there)
  • feel confused.
  • feel very sleepy.
  • have trouble peeing or you cannot pee at all.

How long does tramadol 50 mg last? ›

This monoamine reuptake inhibition is believed to contribute to its effectiveness as a painkiller. The effects of immediate-release tramadol will be felt for about 4–6 hours, while the extended-release version provides effects for about 12-24 hours.

What drugs give a false positive for tramadol? ›

We report two patients that used 180 mg daily dose of fexofenadine hydrochloride for treatment of skin allergy and, falsely, tested positive for use of tramadol during urine drug screening. We recommend caution when interpreting positive tramadol urine screening among patients on fexofenadine treatment.

What will mess up a urine test? ›

Clinically, a false positive urine drug screen can be due to numerous xenobiotics: dextromethorphan, diphenhydramine, doxylamine, ibuprofen, imipramine, ketamine, meperidine, venlafaxine, buproprion, methylenedioxpyrolvalerone (MDPV), and tramadol.

What happens if you test positive for a drug test but have a prescription? ›

Positive drug test results that are explained by a legitimate medical explanation, such as a valid prescription, will not be reported to a federal agency. See (Medical Review Officer Guidance Manual), Chapter 4.5.

Why is tramadol banned? ›

Tramadol misuse is of concern because of the risks of physical dependence, opiate addiction and overdose, and it has become a controlled drug in many countries. Research studies funded by WADA have also confirmed the potential for tramadol to enhance sports performance.

Why don't doctors prescribe tramadol? ›

If your kidney or liver function is impaired, your doctor may decide that tramadol is not appropriate for you. There are other factors that may limit your use of tramadol — for example, if you drink alcohol or take other medicines that can cause drowsiness.

Is tramadol stronger than gabapentin? ›

Although it's not as potent as tramadol, gabapentin is addictive. Its ability to produce sedation and activate the release of certain neurotransmitters makes it a common drug of abuse, especially when multiple depressants are taken at a time.

Can I drink 12 hours after taking tramadol? ›

If you have taken a dose of tramadol, it is safest to wait until the tramadol is completely out of your system before having a drink. Short-acting tramadol has a half-life of around 6.3 hours, meaning that it takes that long for your body to clear half the drug from your system.

What happens if you take tramadol every day? ›

Long term utilization of tramadol is associated with various neurological disorders like seizures, serotonin syndrome, Alzheimer's disease and Parkinson's disease. Tramadol produces seizures through inhibition of nitric oxide, serotonin reuptake and inhibitory effects on GABA receptors.

Can I take 2 extra strength Tylenol with tramadol? ›

Interactions between your drugs

No interactions were found between tramadol and Tylenol Extra Strength.

How much is too much tramadol? ›

How Much Tramadol Is Too Much? Doctors recommend that patients take no more than 50 mg of short-acting tramadol every six hours as needed, or 100 mg of long-acting tramadol per day when starting out. This amount may be increased as tolerances do.

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