Flexeril vs. Ultram Prescription Treatment for Back Pain: Differences and Side Effects (2024)

  • Are Flexeril and Ultram the Same Thing?
  • What Are Possible Side Effects of Flexeril?
  • What Are Possible Side Effects of Ultram?
  • What Is Flexeril?
  • What Is Ultram?
  • What Drugs Interact With Flexeril?
  • What Drugs Interact With Ultram?
  • How Should Flexeril Be Taken?
  • How Should Ultram Be Taken?

Are Flexeril and Ultram the Same Thing?

Flexeril (cyclobenzaprine) and Ultram (tramadol) are used to treat back pain.

Flexeril is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Ultram is used to treat moderate to moderately severe pain in adults.

Flexeril and Ultram belong to different drug classes. Flexeril is a muscle relaxant and Ultram is a pain reliever (analgesic).

Side effects of Flexeril and Ultram that are similar include headache, drowsiness, dizziness, stomach pain or upset, nausea, diarrhea, or constipation.

Side effects of Flexeril that are different from Ultram include dry mouth or throat, blurred vision, fatigue, loss of appetite, gas, or muscle weakness.

Side effects of Ultram that are different from Flexeril include agitation, nervousness, anxiety, seizures (convulsions), skin rash, spinning sensation, hallucinations, fever, fast heart rate, overactive reflexes, vomiting, loss of coordination, and fainting.

Both Flexeril and Ultram may interact with alcohol, other drugs that make you drowsy (narcotics, sleeping pills, muscle relaxers, tranquilizers, sedatives, or medicines for anxiety or seizures), medicines to treat Parkinson's disease, blood pressure medications, and antidepressants.

Flexeril may also interact with atropine, bronchodilators, guanethidine, tramadol, bladder or urinary medications, irritable bowel medications, monoamine oxidase inhibitors (MAOIs), barbiturates, bupropion, cold or allergy medicine that contains an antihistamine, and medicines to treat excess stomach acid or stomach ulcer and motion sickness.

Ultram may also interact with antibiotics, antifungal medications, heart medications, medicines to treat HIV or hepatitis C, antipsychotic medicines, and migraine headache medicines, medicines to treat serious infections.

Do not stop using Ultram suddenly, or you could have unpleasant withdrawal symptoms.

What Are Possible Side Effects of Flexeril?

Common side effects of Flexeril include:

  • dry mouth or throat
  • headache
  • blurred vision
  • drowsiness
  • dizziness
  • fatigue
  • loss of appetite
  • stomach pain
  • nausea
  • diarrhea
  • constipation
  • gas, or
  • muscle weakness.

What Are Possible Side Effects of Ultram?

Common side effects of Ultram include:

  • agitation,
  • nervousness,
  • anxiety,
  • seizures (convulsions),
  • skin rash,
  • dizziness,
  • spinning sensation,
  • hallucinations,
  • fever,
  • fast heart rate,
  • overactive reflexes,
  • nausea,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • constipation,
  • loss of coordination,
  • headache,
  • drowsiness, and
  • fainting.

What Is Flexeril?

Flexeril (cyclobenzaprine) is a muscle relaxant indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

What Is Ultram?

Ultram is a strong prescription pain medicine that contains an opioid (narcotic) that is used for the management pain inadults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or youcannot tolerate them. Ultram is an opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly asprescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death.

What Drugs Interact With Flexeril?

Flexeril especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

What Drugs Interact With Ultram?

Ultram is contraindicated in patients receiving MAO inhibitors or who have used them within the previous 14 days.

The use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.

How Should Flexeril Be Taken?

For most patients, the recommended dose of Flexeril is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of Flexeril for periods longer than two or three weeks is not recommended.

How Should Ultram Be Taken?

Do not change your dose. Take Ultram exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed.

Take your prescribed dose as indicated by your health care provider. The maximum dosage is 1 or 2 tablets every 4 to 6 hours, as needed for pain relief. Do not take more than your prescribed dose and do not take more than 8 tablets per day. If you miss a dose, take your next dose at your usual time.

Call your healthcare provider if the dose you are taking does not control your pain.

If you have been taking Ultram regularly, do not stop taking Ultram without talking to your healthcare provider.

After you stop taking Ultram, ask your pharmacist how to dispose of any unused tablets.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

FDA. Flexeril Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017821s051lbl.pdf

Janssen. Ultram Product Information

http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/ULTRAM-pi.pdf

Flexeril vs. Ultram Prescription Treatment for Back Pain: Differences and Side Effects (2024)

FAQs

Flexeril vs. Ultram Prescription Treatment for Back Pain: Differences and Side Effects? ›

Side effects of Flexeril and Ultram that are similar include headache, drowsiness, dizziness, stomach pain or upset, nausea, diarrhea, or constipation. Side effects of Flexeril that are different from Ultram include dry mouth or throat, blurred vision, fatigue, loss of appetite, gas, or muscle weakness.

What are the side effects of Ultram in the elderly? ›

However, elderly patients are more likely to have unwanted side effects (eg, constipation, lightheadedness, dizziness, or fainting, stomach upset, weakness) and age-related liver, kidney, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving tramadol.

What are the worst side effects of tramadol? ›

Serious side effects
  • feel dizzy, tired and have low energy – these can be a sign of low blood pressure.
  • have hallucinations (seeing or hearing things that are not there)
  • feel confused.
  • feel very sleepy.
  • have trouble peeing or you cannot pee at all.

Who should not take Ultram? ›

Conzip® extended-release capsules, Qdolo® oral liquid, and Ultram® tablets should not be used in children younger than 12 years of age. It should not be used to relieve pain after surgery removal of tonsils or adenoids in any children.

Does Flexeril help with spine pain? ›

Narrative: The muscle relaxant cyclobenzaprine (Flexeril) is a common medication for low back pain that is used to reduce muscle spasm as an adjunct to pain control with nonnarcotic analgesics.

What organ does tramadol damage? ›

Long-term use of tramadol can cause damage to the liver and kidneys. Tramadol can also cause serious and life-threatening breathing problems. Serotonin syndrome may also occur as a result of tramadol use. Serotonin syndrome involves mental status changes, neuromuscular hyperactivity, and autonomic hyperactivity.

Why is tramadol bad for the elderly? ›

Tramadol can cause constipation, nausea, and dizziness; these effects can be particularly problematic in older adults and those with comorbidities. One of the most significant risks associated with tramadol use is the potential for dependence and addiction.

Why is tramadol not recommended? ›

What are the risks associated with tramadol? Opioids are strong pain-relief medicines and can cause life-threatening breathing problems. Tramadol may make it difficult for you to drive or operate heavy machinery due to drowsiness.

Why is it bad to take tramadol? ›

Tramadol use has been linked with serotonin syndrome. This is a potentially life-threatening condition where the serotonin receptors are overstimulated. Serotonin syndrome can lead to high fever, rapid pulse, shivering, sweating, trembling, muscle twitches, agitation and confusion.

What cannot be taken with tramadol? ›

2. Medications and substances that slow down the brain
  • Benzodiazepines like alprazolam (Xanax)
  • Sleep medications like zolpidem (Ambien, Edluar, and ZolpiMist)
  • Barbiturates like phenobarbital.
  • Muscle relaxants like methocarbamol.
  • Diphenhydramine (Benadryl)
  • Other opioids like oxycodone.
  • Alcohol.
Sep 21, 2022

Can a 70 year old take tramadol? ›

However, elderly patients are more likely to have unwanted side effects (eg, constipation, lightheadedness, dizziness, or fainting, stomach upset, weakness) and age-related liver, kidney, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving tramadol.

Why can't you take Tylenol with tramadol? ›

The combination of tramadol and acetaminophen may increase the risk of serotonin syndrome. This risk is possible if you have certain medical problems or are taking certain medications. Symptoms of serotonin syndrome may include: agitation.

What are the black box warnings for Ultram? ›

ADDICTION, ABUSE AND MISUSE ULTRAM exposes patients and other users to the risks of opioid addiction, abuse and misuse, which can lead to overdose and death.

What is the safest muscle relaxer for the elderly? ›

The Geriatric Lexi-Drugs database recommends the avoidance of muscle relaxants other than diazepam and tizanidine in patients older than age 65 years because efficacy and safety have not been established in geriatric patients.

Will Flexeril help a bulging disc? ›

Other medications your doctor could recommend to ease the bulging disc symptoms include: Muscle relaxers – Your doctor could prescribe medications like Flexeril and Skelaxin if you currently have muscle spasms. Some side effects you should anticipate once you take these medications include sedation and dizziness.

Will Flexeril help sciatica? ›

While muscle relaxants and other forms of medication often provide symptomatic relief, they are not a lasting solution to sciatica. At best, they only improve the pain associated with this condition, rather than permanently resolving the condition itself.

Can tramadol cause dementia like symptoms? ›

Cognitive impairment, manic symptoms, psychotic symptoms, and anxiety symptoms are tramadol users' most common psychiatric symptoms [9, 12,13,14,15,16]. Long-term tramadol use was also linked to neurological disorders such as seizures and degenerative conditions like Alzheimer's and Parkinson's [17].

How much tramadol can an elderly person take? ›

Older adults over 75 years of age—At first, 25 mg per day, taken every morning. Your doctor may increase your dose as needed and tolerated. However, the dose is usually not more than 300 mg per day. Children 12 years of age and older—Use and dose must be determined by your doctor.

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