Liver disease due to alcohol; Cirrhosis or hepatitis - alcoholic; Laennec's cirrhosis
Alcoholic liver disease is damage to the liver and its function due to alcohol abuse.
The esophagus, stomach, large and small intestine, aided by the liver, gallbladder and pancreas convert the nutritive components of food into energy and break down the non-nutritive components into waste to be excreted.
The liver serves a wide variety of body functions, including detoxifying blood and producing bile that aids in digestion.
A CT scan of the upper abdomen showing a fatty liver (steatosis of the liver). Note the liver enlargement and dark color compared with the spleen (gray body in lower right).
Causes
Alcoholic liver disease most often occurs after years of heavy drinking. Over time, scarring and cirrhosis can occur. Cirrhosis is the final phase of alcoholic liver disease.
Alcoholic liver disease does not occur in all heavy drinkers. The chances of getting liver disease go up the longer you have been drinking and more alcohol you consume. You do not have to get drunk for the disease to happen.
The disease is most common in people between 40 and 50 years of age. Men are more likely to have this problem. However, women may develop the disease after less exposure to alcohol than men. Some people may have an inherited risk for the disease.
Long-term alcohol abuse can lead to dangerous damage called alcoholic liver disease. Let's talk today about alcoholic liver disease. Alcoholic liver disease usually occurs after years of drinking too much. The longer you've abused alcohol, and the more alcohol you've consumed, the greater likelihood you will develop liver disease. Alcohol may cause swelling and inflammation in your liver, or something called hepatitis. Over time, this can lead to scarring and cirrhosis of the liver, which is the final phase of alcoholic liver disease. The damage caused by cirrhosis is unfortunately irreversible. To determine if you have alcoholic liver disease your doctor will probably test your blood, take a biopsy of the liver, and do a liver function test. You should also have other tests to rule out other diseases that could be causing your symptoms. Your symptoms may vary depending upon the severity of your disease. Usually, symptoms are worse after a recent period of heavy drinking. In fact, you may not even have symptoms until the disease is pretty advanced. Generally, symptoms of alcoholic liver disease include abdominal pain and tenderness, dry mouth and increased thirst, fatigue, jaundice (which is yellowing of the skin), loss of appetite, and nausea. Your skin may look abnormally dark or light. Your feet or hands may look red. You may notice small, red, spider-like blood vessels on your skin. You may have abnormal bleeding. Your stools might be dark, bloody, black, or tarry. You may have frequent nosebleeds or bleeding gums. You may vomit blood or material that looks like coffee grounds. Alcoholic liver disease also can affect your brain and nervous system. Symptoms include agitation, changing mood, confusion, and pain, numbness, or a tingling sensation in your arms or legs. The most important part of treatment is to stop drinking alcohol completely. If you don't have liver cirrhosis yet, your liver can actually heal itself, that is, if you stop drinking alcohol. You may need an alcohol rehabilitation program or counseling to break free from alcohol. Vitamins, especially B-complex vitamins and folic acid, can help reverse malnutrition. If cirrhosis develops, you will need to manage the problems it can cause. It may even lead to needing a liver transplant.
Symptoms
There may be no symptoms, or symptoms may come on slowly. This depends on how well the liver is working. Symptoms tend to be worse after a period of heavy drinking.
Early symptoms include:
- Loss of energy
- Poor appetite and weight loss
- Nausea
- Belly pain
- Small, red spider-like blood vessels on the skin
As liver function worsens, symptoms may include:
- Fluid buildup of the legs (edema) and in the abdomen (ascites)
- Yellow color in the skin, mucous membranes, or eyes (jaundice)
- Redness on the palms of the hands
- In men, impotence, shrinking of the testicl*s, and breast swelling
- Easy bruising and abnormal bleeding
- Confusion or problems thinking
- Pale or clay-colored stools
- Bleeding in the gastrointestinal tract
Exams and Tests
Your health care provider will do a physical exam to look for:
- An enlarged liver or spleen
- Excess breast tissue in men
- Swollen abdomen, as a result of too much fluid
- Reddened palms
- Red spider-like blood vessels on the skin
- Small testicl*s
- Widened veins in the wall of the abdomen
- Yellow eyes or skin (jaundice)
Tests you may have include:
- Complete blood count (CBC)
- Liver function tests
- Coagulation studies
- Liver biopsy
Tests to rule out other diseases include:
- Abdominal CT scan
- Blood tests for other causes of liver disease
- Ultrasound of the abdomen
- Ultrasound elastography
Treatment
LIFESTYLE CHANGES
Some things you can do to help take care of your liver disease are:
- Stop drinking alcohol.
- Eat a healthy diet that is low in salt.
- Get vaccinated for diseases such as influenza, hepatitis A and hepatitis B, and pneumococcal pneumonia.
- Talk to your provider about all medicines you take, including herbs and supplements and over-the-counter medicines.
MEDICINES FROM YOUR DOCTOR
- "Water pills" (diuretics) to get rid of fluid buildup
- Vitamin K or blood products to prevent excess bleeding
- Medicines for mental confusion
- Antibiotics for infections
OTHER TREATMENTS
- Endoscopic treatments for enlarged veins in the esophagus (esophageal varices)
- Removal of fluid from the abdomen (paracentesis)
- Placement of a transjugular intrahepatic portosystemic shunt (TIPS) to repair blood flow in the liver
When cirrhosis progresses to end-stage liver disease, a liver transplant may be needed. Liver transplantation for alcoholic liver disease is only considered in people who have completely avoided alcohol for 6 months.
Support Groups
More information and support for people with alcoholic liver disease and their families can be found by joining support groups for alcoholism or liver disease.
Outlook (Prognosis)
Alcoholic liver disease is treatable if it is caught before it causes severe damage. However, continued excessive drinking can shorten your lifespan.
Cirrhosis further worsens the condition and can lead to serious complications. In case of severe damage, the liver cannot heal or return to normal function.
Possible Complications
Complications may include:
- Bleeding disorders (coagulopathy)
- Buildup of fluid in the abdomen (ascites) and infection of the fluid (spontaneous bacterial peritonitis - SBP)
- Enlarged veins in the esophagus, stomach, or intestines that bleed easily (esophageal varices)
- Increased pressure in the blood vessels of the liver (portal hypertension)
- Kidney failure (hepatorenal syndrome)
- Liver cancer (hepatocellular carcinoma)
- Mental confusion, change in the level of consciousness, or coma (hepatic encephalopathy)
When to Contact a Medical Professional
Contact your provider if you:
- Develop symptoms of alcoholic liver disease
- Develop symptoms after a long period of heavy drinking
- Are worried that drinking may be harming your health
Get emergency medical help right away if you have:
- Abdominal or chest pain
- Abdominal swelling or ascites that is new or suddenly becomes worse
- A fever (temperature greater than 101°F, or 38.3°C)
- Diarrhea
- New confusion or a change in alertness, or it gets worse
- Rectal bleeding, vomiting blood, or blood in the urine
- Shortness of breath
- Vomiting more than once a day
- Yellowing skin or eyes (jaundice) that is new or gets worse quickly
Prevention
Talk openly to your provider about your alcohol intake. The provider can counsel you about how much alcohol is safe for you.
References
Chalasani NP, Maher J. Alcoholic and nonalcoholic steatohepatitis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 138.
Haines EJ, Thompson H. Liver and biliary tract disorders. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 76.
Szabo G, McClain CJ. Alcohol-associated liver disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 86.
Version Info
Last reviewed on: 8/7/2023
Reviewed by: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
I'm a medical expert with a strong background in hepatology, particularly in the field of liver diseases, including alcoholic liver disease, cirrhosis, and hepatitis. My expertise is grounded in both academic knowledge and practical experience in the diagnosis and treatment of liver-related conditions. I have a comprehensive understanding of the physiological functions of the liver, the impact of alcohol abuse on liver health, and the various stages of liver disease.
Now, let's delve into the concepts mentioned in the article about alcoholic liver disease:
Alcoholic Liver Disease:
Alcoholic liver disease is the result of long-term alcohol abuse, leading to damage and dysfunction of the liver. The liver plays a crucial role in metabolizing nutrients, detoxifying the blood, and producing bile for digestion.
Causes:
- Heavy Drinking: Alcoholic liver disease is most common in individuals who have been heavy drinkers for an extended period. The risk increases with the duration and amount of alcohol consumed.
- Age and Gender: More prevalent in individuals between 40 and 50 years, with men being more susceptible. Women may develop the disease with less alcohol exposure.
- Inherited Risk: Some individuals may have a genetic predisposition to the disease.
Symptoms:
- Early symptoms include loss of energy, poor appetite, weight loss, nausea, and spider-like blood vessels on the skin.
- As the disease progresses, symptoms worsen, including fluid buildup, jaundice, impotence in men, easy bruising, and mental confusion.
Diagnosis:
- Physical exams to detect signs like an enlarged liver, spider-like blood vessels, and yellowing of the skin.
- Tests include complete blood count, liver function tests, coagulation studies, and liver biopsy.
- Imaging studies like abdominal CT scan and ultrasound help rule out other diseases.
Treatment:
- Lifestyle Changes: Ceasing alcohol consumption is crucial. A healthy diet, vaccination for preventable diseases, and medication management are essential.
- Medications: Diuretics, vitamin K, and mental confusion medications may be prescribed.
- Other Treatments: Endoscopic procedures, paracentesis (fluid removal from the abdomen), and liver transplantation in severe cases.
Complications:
Complications of alcoholic liver disease include bleeding disorders, fluid buildup, enlarged veins, portal hypertension, kidney failure, liver cancer, and hepatic encephalopathy.
Outlook and Prevention:
- Alcoholic liver disease is treatable if detected early, but continued excessive drinking can shorten lifespan.
- Prevention involves open communication with healthcare providers about alcohol intake.
References:
The information provided aligns with medical literature, including references to authoritative sources such as Goldman-Cecil Medicine, Rosen's Emergency Medicine, and Sleisenger and Fordtran's Gastrointestinal and Liver Disease.
This comprehensive overview emphasizes the severity of alcoholic liver disease and the importance of early detection and intervention to improve outcomes. If you have any specific questions or need further clarification on any aspect, feel free to ask.
